Peter FergusonMD, MSc, FRCSC
Albert and Temmy Latner Chair
Division of Orthopaedics
Department of Surgery, University of Toronto
(416) 586-4800 x8687
Mount Sinai Hospital
600 University Avenue, Suite 476(G)
Toronto, ON M5G 1X5
Areas of Specialty and Research Interests
Tissue engineering techniques to enhance impaired wound healing. We have observed that patients who undergo radiation prior to surgical excision of sarcomas in the extremities have a high incidence of wound healing complications. Our focus is on elucidating the mechanisms whereby radiation impairs wound healing and also to examine various interventions to overcome this deficit. Currently we are exploring two areas: cell therapy, using bone marrow stromal cells that can differentiate into wound healing fibroblasts; and use of synthetic materials to act as wound fillers and that can harbour cell growth prior to implantation.
Biomechanical modeling of metastatic lesions in long bones. Metastases are the most common neoplasia presenting in the skeleton and cause significant disability and morbidity. We have an interest in finite element modeling of metastatic lesions in the femur and humerus to determine lesions that are at greatest risk of pathologic fracture. Furthermore, we wish to examine different types of fixation of metastatic lesions using finite element analysis and cadaver biomechanical testing.