Dr. O’Keefe is the Fred C. Reynolds Professor and Chair of the Department of Orthopaedic Surgery at Washington University School of Medicine. He is an orthopaedic surgeon specializing in musculoskeletal oncology and adult reconstructive surgery of the hip and knee. He has clinical interests in the management of benign and malignant bone and soft (connective) tissue tumors in both children and adults, bone infections, skeletal reconstruction, curettage of bone tumors and allograft procedures, and primary and revision total hip and total knee arthroplasty.

Dr. O’Keefe received his medical degree from Harvard Medical School in 1985 and completed a surgical internship from Harvard Medical School/New England Deaconess Hospital in 1986. He served as an Instructor/Fellow of Research at the University of Rochester, School of Medicine and Dentistry until 1988, where he then went on to complete an orthopaedic surgery residency at the University of Rochester Medical Center in 1992. He then completed a Fellowship in Orthopaedic Oncology at the Massachusetts General Hospital in 1993. Following his fellowship, Dr. O’Keefe returned to the University of Rochester where he served as a member of the faculty, completed a doctorate degree in biochemistry and biophysics, and eventually served as the Marjorie Strong Wehle Professor and the Chair of the Department of Orthopaedics.